Indinavir – What You Need to Know

If you or a loved one has been prescribed Indinavir, you probably have a lot of questions. This guide breaks down the basics so you can feel confident about taking the drug. Indinavir is a protease inhibitor used to treat HIV‑1 infection. It works by stopping the virus from making new copies, helping your immune system stay strong.

Most people start with a dose of 800 mg twice a day, taken on an empty stomach. Your doctor may adjust the amount based on your weight, kidney function, and how well you tolerate the medication. Always follow the exact schedule your doctor gives you – missing doses can let the virus bounce back.

How to Take Indindavir Correctly

Take Indinavir with a full glass of water (at least 250 ml). Drinking enough water is crucial because the drug can cause kidney stones if it stays concentrated in your urine. Aim to stay hydrated throughout the day—about 2‑3 liters total, depending on your activity level.

Don’t take the tablet with food or antacids, as they can lower absorption. If you forget a dose, take it as soon as you remember, but if it’s almost time for the next dose, skip the missed one and continue as normal. Double‑dosing can increase side effects without extra benefit.

Store the tablets at room temperature, away from moisture and heat. Keep them out of reach of children and pets.

Key Side Effects and What to Watch For

Most people tolerate Indinavir well, but some side effects are common. The most frequent are nausea, diarrhea, and mild headache. These usually improve after a few days. If you experience severe stomach pain, vomiting, or persistent diarrhea, contact your doctor—these could signal a more serious issue.

Indinavir can raise bilirubin levels, leading to a yellowish tint in the skin or eyes. While this is often harmless, it’s worth a quick check with your doctor if you notice any color change.

A bigger concern is kidney stones. Symptoms include sharp flank pain, blood in the urine, or frequent urination. Stay well‑hydrated and let your doctor know right away if you suspect a stone.

Rarely, people develop rash, fever, or signs of an allergic reaction. If you get hives, swelling, or trouble breathing, seek emergency care.

Because Indinavir can affect blood lipids, your doctor may order regular cholesterol checks. Lifestyle tweaks—like a balanced diet and regular exercise—can help keep levels in check.

Lastly, don’t mix Indinavir with certain drugs without checking first. It interacts with some antibiotics (e.g., clarithromycin), antifungals (e.g., ketoconazole), and other HIV medicines. Always give your pharmacist a full list of what you’re taking.

In summary, taking Indinavir correctly means timing, hydration, and awareness of side effects. Stick to the prescribed schedule, drink plenty of water, and keep an eye on any new symptoms. If you stay proactive, Indinavir can be a powerful tool in managing HIV while minimizing risks.